Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774200 | 0.84 | LCK (0.77) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL772206 | 0.80 | LCK (0.67) | LCKALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL773950 | 0.80 | LCK (0.67) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5607804 | 0.78 | LCK (0.71) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL18047823 | 0.78 | LCK (0.65) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL773819 | 0.78 | LCK (1.00) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL773488 | 0.77 | LCK (0.82) | LCK | |
| SCHEMBL774793 | 0.77 | LCK (1.00) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL774406 | 0.77 | LCK (0.64) | LCKRAB9ASMN1; SMN2MAPT | |
| SCHEMBL5608004 | 0.77 | LCK (0.69) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222619-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | Bristol-Myers Squibb Holdings Ireland (CH) | 2017-09-27 | — | — | EP | disclosed |
| EP-1169038-B9 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-1169038-B1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-2308833-A2 | Cyclic protein tyrosine kinase inhibitors | Bristol-Myers Squibb Company (US) | 2011-04-13 | — | — | EP | disclosed |