Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.74 |
| ▸ | MAOA | P21397 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | MITF | O75030 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.64 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.61 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | MAX | P61244 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | FABP4 | P15090 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15400058 | 1.00 | CISD1 (0.74) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL12008437 | 1.00 | CISD1 (0.74) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL12008457 | 0.93 | FFAR1 (0.74) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL7958266 | 0.93 | MAPT (0.72) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL7958261 | 0.93 | MAPT (0.72) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL17319555 | 0.88 | PTPN12 (0.72) | KMT2AAKR1B1MEN1PTPN1 | |
| SCHEMBL14905165 | 0.87 | CISD1 (0.79) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL12008748 | 0.87 | CISD1 (0.79) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL6888297 | 0.87 | MAPT (0.59) | CISD1MAOAMAPTNCOA3ALDH1A1 | |
| SCHEMBL18420883 | 0.85 | CISD1 (0.81) | CISD1MAOAMAPTNCOA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206412-B2 | Thioxothiazolidine inhibitors | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2015-12-08 | — | — | US | disclosed |
| US-20140004590-A1 | THIOXOTHIAZOLIDINE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-01-02 | — | — | US | disclosed |