Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.79 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15401323 | 1.00 | MET (0.79) | METJAK2ALK | |
| SCHEMBL15401103 | 0.93 | MET (0.72) | METJAK2ALK | |
| SCHEMBL15401102 | 0.93 | MET (0.72) | METJAK2ALK | |
| SCHEMBL488753 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL30753168 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL16241930 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL30753162 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL1823429 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL29858462 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL15400862 | 0.85 | MET (0.85) | METJAK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9707218-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9707218-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150366853-A1 | Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150366853-A1 | Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-9145390-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145390-B2 | Derivatives of pyrazole-substituted amino-heteroaryl compounds | CONCERT PHARMACEUTICALS, INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20140005211-A1 | DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS | CONCERT PHARMACEUTICALS, INC. (US) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366853-A1 | Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds | ALK, ABL1, MALT1 | MET 298/4885JAK2 9/4885ALK 1/4885 |
| US-20140005211-A1 | DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS | ALK, ABL1, MALT1 | MET 298/4885JAK2 9/4885ALK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.