Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.79 |
| ▸ | MST1R | Q04912 | 6/20 | 0.79 |
| ▸ | KDR | P35968 | 5/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.79 |
| ▸ | TEK | Q02763 | 4/20 | 0.79 |
| ▸ | BTK | Q06187 | 4/20 | 0.79 |
| ▸ | HGF | P14210 | 3/20 | 0.79 |
| ▸ | EGFR | P00533 | 3/20 | 0.79 |
| ▸ | FLT4 | P35916 | 3/20 | 0.79 |
| ▸ | JAK2 | O60674 | 2/20 | 0.79 |
| ▸ | FLT1 | P17948 | 2/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.79 |
| ▸ | AURKA | O14965 | 3/20 | 0.60 |
| ▸ | LCK | P06239 | 3/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15405203 | 0.95 | MET (0.72) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL15404552 | 0.95 | MET (0.71) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL15404511 | 0.95 | MET (0.79) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL15405069 | 0.94 | MET (0.70) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL15406338 | 0.89 | MET (0.63) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL2868963 | 0.88 | MET (1.00) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL29439859 | 0.88 | MET (1.00) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL15405185 | 0.87 | MET (0.77) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL2868521 | 0.84 | MET (0.91) | METMST1RKDRRPS6KB1TEK | |
| SCHEMBL13511860 | 0.84 | MET (0.91) | METMST1RKDRRPS6KB1TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-B1 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC (US) | 2014-01-15 | — | — | EP | claimed |