Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.78 |
| ▸ | RAB9A | P51151 | 10/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
| ▸ | RELA | Q04206 | 1/20 | 0.72 |
| ▸ | CASP3 | P42574 | 1/20 | 0.72 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6802217 | 0.93 | NPC1 (0.83) | NPC1RAB9ASMN1; SMN2TP53RXFP1 | |
| SCHEMBL15412987 | 0.92 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL6439090 | 0.92 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL2917029 | 0.91 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL14130389 | 0.91 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL4248125 | 0.91 | KCNK3 (0.82) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL31179828 | 0.89 | KCNK9 (0.83) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL30949327 | 0.89 | AR (0.87) | NPC1RAB9ASMN1; SMN2TP53RXFP1 | |
| SCHEMBL1003529 | 0.89 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL1352307 | 0.89 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014011660-A1 | METHODS AND COMPOSITIONS FOR INFLUENCING THE TRANSPORT OF MOLECULAR SPECIES THROUGH BIOLOGICAL BARRIERS | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2014-01-16 | — | — | WO | disclosed |