Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413621 | 0.75 | GPR35 (0.46) | GPR35KCNJ5KCNJ3 | |
| SCHEMBL15414003 | 0.73 | GPR35 (0.49) | GPR35 | |
| SCHEMBL15414126 | 0.72 | GPR35 (0.50) | GPR35 | |
| SCHEMBL15414374 | 0.71 | GPR35 (0.49) | GPR35KCNJ5KCNJ3 | |
| SCHEMBL15413595 | 0.70 | GPR35 (0.51) | GPR35ALDH1A1 | |
| SCHEMBL15408019 | 0.69 | GPR35 (0.59) | GPR35 | |
| SCHEMBL11946654 | 0.69 | GPR35 (0.90) | GPR35 | |
| SCHEMBL15414134 | 0.68 | GPR35 (0.49) | GPR35 | |
| SCHEMBL15408016 | 0.68 | GPR35 (0.55) | GPR35 | |
| SCHEMBL15413767 | 0.68 | GPR35 (0.51) | GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872514-A1 | IMIDAZOTRIAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014011974-A1 | IMIDAZOTRIAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-16 | — | — | WO | disclosed |