Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15415398 | 0.86 | CYP3A4 (0.41) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL15415033 | 0.84 | CYP3A4 (0.40) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL1708410 | 0.83 | CYP3A4 (0.46) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL16909548 | 0.81 | CYP3A4 (0.44) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL1282712 | 0.70 | CYP3A4 (0.44) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL21868475 | 0.70 | CYP3A4 (0.44) | CYP3A4PTPN11ALDH1A1CYP2C9MAPK1 | |
| SCHEMBL1282674 | 0.68 | CYP3A4 (0.44) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL1708664 | 0.68 | CYP3A4 (0.44) | CYP3A4CYP2D6USP2PTPN11ACACB | |
| SCHEMBL15577957 | 0.66 | FAAH (0.43) | CYP3A4PTPN11SMN1; SMN2KDM4E | |
| SCHEMBL15415031 | 0.66 | CYP3A4 (0.40) | CYP3A4CYP2D6USP2PTPN11ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872508-A1 | IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SPRL (BE) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009295-A1 | IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB PHARMA S.A. (BE) | 2014-01-16 | — | — | WO | disclosed |