Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 11/20 | 0.63 |
| ▸ | BAD | Q92934 | 4/20 | 0.62 |
| ▸ | BCL2L1 | Q07817 | 12/20 | 0.61 |
| ▸ | BCL2L2 | Q92843 | 3/20 | 0.61 |
| ▸ | BCL2L11 | O43521 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.61 |
| ▸ | ASPH | Q12797 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | MDM4 | O15151 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | BID | P55957 | 1/20 | 0.57 |
| ▸ | BAX | Q07812 | 1/20 | 0.57 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.57 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.57 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14463310 | 0.93 | BCL2 (0.64) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL12574586 | 0.93 | BCL2 (0.63) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL7872304 | 0.88 | BCL2L1 (0.67) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL19425214 | 0.86 | BCL2 (0.73) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL19425083 | 0.86 | BCL2 (0.73) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL19424240 | 0.86 | BCL2 (0.72) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL19424355 | 0.85 | BCL2 (0.74) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL1628848 | 0.85 | BCL2L1 (0.79) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL2020908 | 0.85 | BCL2L1 (0.79) | BCL2BADBCL2L1BCL2L2BCL2L11 | |
| SCHEMBL19425549 | 0.84 | BCL2L1 (0.73) | BCL2BADBCL2L1BCL2L2BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8624027-B2 | Combination therapy for treating cancer and diagnostic assays for use therein | ABBVIE INC. (US) | 2014-01-07 | — | — | US | disclosed |