Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734149 | 0.88 | SCN9A (0.41) | SCN9APIK3CANR4A2TGFBR1GSK3B | |
| SCHEMBL3767529 | 0.86 | KDM4E (0.45) | SCN9APIK3CANR4A2IRAK4KDM4E | |
| SCHEMBL15419111 | 0.83 | MAPT (0.42) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15418870 | 0.82 | SYK (0.37) | PIK3CANR4A2TGFBR1KDM4ENPC1 | |
| SCHEMBL1733967 | 0.80 | NR4A2 (0.48) | SCN9ANR4A2IRAK4MAP3K5 | |
| SCHEMBL15418875 | 0.80 | PIK3CA (0.42) | PIK3CATGFBR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL15418891 | 0.76 | NR4A2 (0.50) | NR4A2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL15418922 | 0.73 | PIK3CA (0.39) | PIK3CAKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL1734134 | 0.73 | KDM4E (0.53) | NR4A2IRAK4KDM4ENPC1RAB9A | |
| SCHEMBL12170348 | 0.72 | SCN9A (0.52) | SCN9ANPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |