Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15418937 | 0.83 | PIK3CA (0.38) | PIK3CAKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL1733303 | 0.83 | ALDH1A1 (0.38) | PIK3CAKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3764591 | 0.82 | KDM4E (0.55) | KDM4EPOLBALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL15418816 | 0.82 | MAP3K5 (0.48) | PIK3CAKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL15418891 | 0.81 | NR4A2 (0.50) | KDM4EPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL15418946 | 0.81 | PIK3CA (0.36) | PIK3CAKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL15418875 | 0.80 | PIK3CA (0.42) | PIK3CAKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL16685207 | 0.77 | KDM4E (0.41) | PIK3CAKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL15418868 | 0.76 | ADORA2A (0.52) | KDM4EPOLBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL15418923 | 0.76 | KDM4E (0.39) | KDM4EPOLBALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |