Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 12/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15419094 | 0.91 | L3MBTL1 (0.57) | HIF1AL3MBTL1MEN1KMT2AEGLN1 | |
| SCHEMBL15419109 | 0.91 | L3MBTL1 (0.52) | HIF1AL3MBTL1MEN1KMT2AEGLN1 | |
| SCHEMBL15419125 | 0.91 | HIF1A (0.56) | HIF1AL3MBTL1MEN1KMT2AGSK3B | |
| SCHEMBL2382749 | 0.83 | L3MBTL1 (0.55) | HIF1AL3MBTL1MEN1KMT2AEGLN1 | |
| SCHEMBL2382746 | 0.83 | L3MBTL1 (0.55) | HIF1AL3MBTL1MEN1KMT2AEGLN1 | |
| SCHEMBL2384965 | 0.83 | L3MBTL1 (0.57) | HIF1AL3MBTL1MEN1KMT2A | |
| SCHEMBL2384968 | 0.83 | L3MBTL1 (0.57) | HIF1AL3MBTL1MEN1KMT2A | |
| SCHEMBL2382306 | 0.82 | EGLN1 (0.67) | HIF1AL3MBTL1MEN1KMT2AGSK3B | |
| SCHEMBL2383427 | 0.82 | L3MBTL1 (0.54) | HIF1AL3MBTL1MEN1KMT2AEGLN1 | |
| SCHEMBL2382301 | 0.82 | EGLN1 (0.67) | HIF1AL3MBTL1MEN1KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-B1 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS AND USES THEREOF | AMGEN INC (US) | 2014-01-22 | — | — | EP | claimed |