Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15419154 | 0.82 | HDAC4 (0.53) | EGFRSRCHIF1ATSHRMEN1 | |
| SCHEMBL10676787 | 0.82 | EGFR (0.70) | EGFRSRCHIF1ATSHRCYP19A1 | |
| SCHEMBL2382224 | 0.82 | HIF1A (0.53) | EGFRSRCHIF1ATSHRCYP19A1 | |
| SCHEMBL2383861 | 0.82 | HIF1A (0.64) | HIF1A | |
| SCHEMBL2383323 | 0.81 | CYP19A1 (0.52) | EGFRSRCHIF1ATSHRCYP19A1 | |
| SCHEMBL2384819 | 0.80 | L3MBTL1 (0.49) | EGFRSRCHIF1ATSHRCYP19A1 | |
| SCHEMBL2384824 | 0.80 | L3MBTL1 (0.49) | EGFRSRCHIF1ATSHRCYP19A1 | |
| SCHEMBL2384899 | 0.80 | MEN1 (0.65) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL12254449 | 0.80 | HIF1A (0.53) | EGFRSRCHIF1ATSHRCYP19A1 | |
| SCHEMBL12254448 | 0.78 | L3MBTL1 (0.47) | EGFRSRCHIF1ATSHRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-B1 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS AND USES THEREOF | AMGEN INC (US) | 2014-01-22 | — | — | EP | claimed |