Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15419106 | 1.00 | GSK3B (0.56) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2382306 | 0.91 | EGLN1 (0.67) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2382301 | 0.91 | EGLN1 (0.67) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2385339 | 0.87 | L3MBTL1 (0.55) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2385340 | 0.87 | L3MBTL1 (0.55) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2384516 | 0.86 | L3MBTL1 (0.54) | EGLN1L3MBTL1MEN1KMT2AHIF1A | |
| SCHEMBL2385209 | 0.86 | L3MBTL1 (0.54) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2384512 | 0.86 | L3MBTL1 (0.54) | EGLN1L3MBTL1MEN1KMT2AHIF1A | |
| SCHEMBL2385208 | 0.86 | L3MBTL1 (0.54) | GSK3BEGLN1L3MBTL1MEN1KMT2A | |
| SCHEMBL2384965 | 0.84 | L3MBTL1 (0.57) | L3MBTL1MEN1KMT2AGAAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-B1 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS AND USES THEREOF | AMGEN INC (US) | 2014-01-22 | — | — | EP | claimed |