Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.83 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | GLA | P06280 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | STAT6 | P42226 | 1/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cositecan SCHEMBL15692672 | 0.94 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| Cositecan SCHEMBL2315201 | 0.94 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| Cositecan SCHEMBL29378211 | 0.94 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL3152675 | 0.93 | TOP1 (0.83) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL4453581 | 0.93 | TOP1 (0.90) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL3156178 | 0.92 | TOP1 (0.79) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL3150912 | 0.92 | TOP1 (0.81) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL11070279 | 0.92 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL27606708 | 0.92 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL3150335 | 0.91 | TOP1 (0.80) | TOP1MEN1KMT2AALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197879-B1 | C7-SUBSTITUTED CAMPTOTHECIN ANALOGS | BIONUMERIK PHARMACEUTICALS INC (US) | 2014-01-22 | — | — | EP | claimed |