Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.90 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | GLA | P06280 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | STAT6 | P42226 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | GMNN | O75496 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728533 | 0.95 | TOP1 (1.00) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL27606708 | 0.94 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL11070279 | 0.94 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL15725385 | 0.93 | TOP1 (0.82) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL4557415 | 0.93 | TOP1 (0.94) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL4455085 | 0.93 | TOP1 (0.94) | TOP1MEN1KMT2AALDH1A1GLA | |
| Cositecan SCHEMBL29378211 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| Cositecan SCHEMBL2315201 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| Cositecan SCHEMBL15692672 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL26976807 | 0.93 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | claimed |
| US-6653319-B1 | Formulating alkaline supersaturated aqueous solution of lipophilic derivative and solubilizer; acidifying | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2003-11-25 | — | — | US | claimed |
| EP-0137145-B1 | NEW CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARING SAME | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1988-04-27 | — | — | EP | claimed |
| US-20240156808-A1 | Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases | EDISON ONCOLOGY (US) | 2024-05-16 | — | — | US | disclosed |
| EP-4297746-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED COMPOUNDS AND THERAPIES FOR THE TREATMENT OF DISEASES | Edison Oncology (US) | 2024-01-03 | — | — | EP | disclosed |
| EP-2920191-B1 | METHODS FOR THE TOTAL CHEMICAL SYNTHESIS OF ENANTIOMERICALLY-PURE 7-(2'-TRIMETHYLSILYL) ETHYL CAMPTOTHECIN | BIONUMERIK PHARMACEUTICALS INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-1883407-A4 | COMPOSITIONS AND METHODS FOR TREATMENT FOR NEOPLASMS | COMBINATORX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1883407-A1 | COMPOSITIONS AND METHODS FOR TREATMENT FOR NEOPLASMS | CombinatoRx, Incorporated (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20060264384-A1 | Compositions and methods for treatment for neoplasms | COMBINATORX, INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006122007-A1 | COMPOSITIONS AND METHODS FOR TREATMENT FOR NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2006-11-16 | — | — | WO | disclosed |
| US-6136978-A | CYCLIZING SILYL COMPOUND WITH ARYL ISONITRILE COMPOUND TO FORM SILYL CAMPTOTHECIN DERIVATIVE | UNIVERSITY OF PITTSBURGH (US) | 2000-10-24 | — | — | US | disclosed |
| US-RE32518-E | Camptothecin derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0074256-B1 | CAMPTOTHECIN DERIVATIVES, PROCESSES FOR PREPARING SAME, FORMULATIONS CONTAINING SUCH DERIVATIVES AND THEIR USE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1986-11-20 | — | — | EP | disclosed |
| US-4545880-A | Photochemical process for preparing camptothecin derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1985-10-08 | — | — | US | disclosed |
| US-4513138-A | Camptothecin-1-oxide derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1985-04-23 | — | — | US | disclosed |
| US-4473692-A | Camptothecin derivatives and process for preparing same | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1984-09-25 | — | — | US | disclosed |
| US-4399282-A | 7-HYDROXYALKYL DERIVATIVES USING FREE RADICAL CATALYSTS; ANTITUMOR AND -CARCINOGENIC AGENTS; NONTOXIC | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1983-08-16 | — | — | US | disclosed |
| EP-0074770-A1 | Camptothecin-1-oxide derivatives, process for preparing same, formulations comprising said derivatives and said derivatives for use in producing an anti-tumour effect | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1983-03-23 | — | — | EP | disclosed |
| EP-0074256-A1 | Camptothecin derivatives, processes for preparing same, formulations containing such derivatives and their use | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1983-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240156808-A1 | Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases | TOP2A, TOP2B, TOP1 | TOP1 3/4885MEN1 601/4885KMT2A 1727/4885 |
| US-20060264384-A1 | Compositions and methods for treatment for neoplasms | MGMT, TP53, HCCS | TOP1 201/4885MEN1 71/4885KMT2A 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.