SCHEMBL15419476

SCHEMBL15419476

Cc1cc2c(cc1-c1sccc1C)c(O)c(C(=O)NCC(=O)O)c(=O)n2C

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 2/20 0.60
HIF1A Q16665 18/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12306159 0.90 EGLN1 (0.48) EGLN1HIF1A
SCHEMBL2382737 0.88 EGLN1 (0.46) EGLN1HIF1A
SCHEMBL2384076 0.86 EGLN1 (0.63) EGLN1HIF1A
SCHEMBL2384881 0.86 EGLN1 (0.60) EGLN1HIF1A
SCHEMBL2385407 0.84 HIF1A (0.62) EGLN1HIF1A
SCHEMBL2496582 0.81 EGLN1 (0.67) EGLN1HIF1A
SCHEMBL15419051 0.81 L3MBTL1 (0.42) EGLN1HIF1A
SCHEMBL2382767 0.79 EGLN1 (0.64) EGLN1HIF1A
SCHEMBL2385726 0.79 EGLN1 (0.56) EGLN1HIF1A
SCHEMBL12254510 0.78 EGLN1 (0.49) EGLN1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1960363-B1 QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS AND USES THEREOF AMGEN INC (US) 2014-01-22 EP claimed