Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.65 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560175 | 0.85 | AXL (0.73) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL20617830 | 0.80 | AXL (0.67) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL1542113 | 0.79 | AXL (1.00) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL29521071 | 0.79 | AXL (0.60) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL30153817 | 0.79 | AXL (0.65) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL24358770 | 0.79 | AXL (0.65) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL359039 | 0.79 | AXL (0.65) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL29664834 | 0.78 | AXL (0.44) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL24511678 | 0.78 | AXL (0.44) | AXLTLR8MKNK1TRPA1TRPM8 | |
| SCHEMBL9917349 | 0.78 | AXL (0.64) | AXLTLR8MKNK1TRPA1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112299-A1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-05-12 | — | — | US | disclosed |
| EP-2308880-A1 | TETRACYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112299-A1 | TETRACYCLIC COMPOUND | REN, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, LPXN | AXL 1385/4885TLR8 3177/4885MKNK1 4365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.