Sugi Predict

Sugi Predict / Compounds / SCHEMBL15420148

SCHEMBL15420148

SCHEMBL15420148

CCS(=O)(=O)N[C@H]1CCCO[C@@H]1COc1ccc(-n2cc(Cl)cn2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RIPK2 O43353 1/20 0.35
▸ NPC1 O15118 5/20 0.34
▸ RAB9A P51151 5/20 0.34
▸ HRH3 Q9Y5N1 1/20 0.33
▸ GCGR P47871 1/20 0.33
▸ CYP46A1 Q9Y6A2 1/20 0.33
▸ ALDH1A1 P00352 4/20 0.32
▸ SMN1; SMN2 Q16637 3/20 0.32
▸ LMNA P02545 2/20 0.32
▸ HPGD P15428 2/20 0.32
▸ HSD17B10 Q99714 2/20 0.32
▸ ALOX15 P16050 1/20 0.32
▸ SCN9A Q15858 2/20 0.32
▸ ALK Q9UM73 2/20 0.32
▸ INSR P06213 1/20 0.32
▸ ROS1 P08922 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21795647 1.00 RIPK2 (0.35) RIPK2NPC1RAB9AHRH3GCGR
SCHEMBL15420980 0.92 RIPK2 (0.36) RIPK2NPC1RAB9AHRH3GCGR
SCHEMBL15420419 0.90 RAB9A (0.38) RIPK2NPC1RAB9AHRH3ALDH1A1
SCHEMBL15420358 0.89 NPC1 (0.34) RIPK2NPC1RAB9AHRH3CYP46A1
SCHEMBL15420035 0.87 CYP46A1 (0.35) RIPK2CYP46A1SCN9AALKINSR
SCHEMBL15420287 0.86 SCN9A (0.35) RIPK2CYP46A1SCN9AALKINSR
SCHEMBL15420522 0.83 CHRM1 (0.35) RIPK2HRH3GCGRCYP46A1
SCHEMBL15420523 0.82 NPC1 (0.44) NPC1RAB9AALDH1A1SMN1; SMN2LMNA
SCHEMBL15420468 0.82 CHRM1 (0.34) RIPK2HRH3GCGRCYP46A1
SCHEMBL15420340 0.82 CHRM1 (0.34) RIPK2HRH3GCGRCYP46A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694472-B1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2020-03-11 — — EP disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF GRIN2A, GRIN2B, SLC1A2 RIPK2 3786/4885NPC1 2770/4885RAB9A 3305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.