Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.43 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GRM8 | O00222 | 2/20 | 0.38 |
| ▸ | GRM6 | O15303 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704175 | 0.81 | SLC6A12 (0.45) | GABRR1SLC6A12SLC6A11GRM4CYP2C19 | |
| Hydrochloric Acid SCHEMBL9114738 | 0.79 | GABRR1 (0.46) | GABRR1SLC6A12SLC6A11GRM4CYP2C19 | |
| Hydrochloric Acid SCHEMBL9114735 | 0.79 | GABRR1 (0.46) | GABRR1SLC6A12SLC6A11GRM4CYP2C19 | |
| Hydrochloric Acid SCHEMBL9114725 | 0.79 | GABRR1 (0.46) | GABRR1SLC6A12SLC6A11GRM4CYP2C19 | |
| SCHEMBL19917125 | 0.78 | KCNQ3 (0.38) | SLC6A12SLC6A11GRM4CYP2C19CYP1A2 | |
| SCHEMBL17803111 | 0.76 | SLC6A12 (0.41) | SLC6A12SLC6A11GRM4CYP2C19CYP1A2 | |
| SCHEMBL19756870 | 0.76 | SLC6A12 (0.41) | SLC6A12SLC6A11GRM4CYP2C19CYP1A2 | |
| SCHEMBL17814235 | 0.76 | SLC6A12 (0.41) | SLC6A12SLC6A11GRM4CYP2C19CYP1A2 | |
| SCHEMBL16635714 | 0.74 | SLC6A12 (0.40) | GABRR1SLC6A12SLC6A11GRM4CYP2C19 | |
| SCHEMBL1770299 | 0.74 | MAPT (0.35) | CYP2C19ALDH1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694472-B1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2020-03-11 | — | — | EP | disclosed |
| US-9527807-B2 | Sulfonamide derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-27 | — | — | US | disclosed |
| US-20140024650-A1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024650-A1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | GRIN2A, GRIN2B, SLC1A2 | GABRR1 214/4885SLC6A12 443/4885SLC6A11 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.