Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.57 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | FOXO3 | O43524 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.57 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.57 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.57 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.57 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.57 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.57 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15422627 | 1.00 | ALDH1A1 (0.57) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL21039243 | 0.87 | ALDH1A1 (0.48) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL15432080 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL21001951 | 0.85 | ALDH1A1 (0.52) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL21001950 | 0.85 | ALDH1A1 (0.52) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL22713020 | 0.85 | ALDH1A1 (0.49) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL21039170 | 0.85 | ALDH1A1 (0.49) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL15422036 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL21039167 | 0.83 | ALDH1A1 (0.45) | ALDH1A1TP53SMN1; SMN2MAPTLMNA | |
| SCHEMBL15422540 | 0.82 | SMN1; SMN2 (0.60) | ALDH1A1TP53SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108923-B2 | Compounds, compositions, and methods for cancer therapy | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2015-08-18 | — | — | US | disclosed |
| US-20140024639-A1 | Compounds, Compositions, and Methods for Cancer Therapy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024639-A1 | Compounds, Compositions, and Methods for Cancer Therapy | MCL1, TP53, VHL | ALDH1A1 710/4885TP53 2/4885SMN1; SMN2 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.