SCHEMBL15423157

COc1c(C(C)(C)C)cc2c(c1-c1ccccc1)C=C(CC(C)(C)C)C2[Si](C)(C)C1C(CC(C)(C)C)=Cc2c1cc(C(C)(C)C)c(OC)c2-c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	PDE4A	P27815	2/20	0.33

▸	PDE4B	Q07343	2/20	0.33

▸	PDE4C	Q08493	2/20	0.33

▸	PDE4D	Q08499	2/20	0.33

▸	TNFRSF1A	P19438	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29873763	0.88	—	—
SCHEMBL20165767	0.88	—	—
SCHEMBL9960113	0.87	PDE4A (0.34)	PDE4APDE4BPDE4CPDE4D
SCHEMBL3736095	0.84	PDE4B (0.35)	PDE4APDE4BPDE4CPDE4DTNFRSF1A
Hydrochloric Acid SCHEMBL15411134	0.83	PDE4B (0.32)	PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL2592074	0.81	PDE4A (0.30)	PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL15410777	0.81	PDE4A (0.30)	PDE4APDE4BPDE4CPDE4D
SCHEMBL21218831	0.81	PDE4A (0.32)	PDE4APDE4BPDE4CPDE4D
SCHEMBL15411135	0.81	PDE4A (0.32)	PDE4APDE4BPDE4CPDE4D
SCHEMBL15424250	0.81	—	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9079985-B2	Bridged metallocene catalysts	BOREALIS AG (AT)	2015-07-14	—	—	US	disclosed
US-9079985-B2	Bridged metallocene catalysts	BOREALIS AG (AT)	2015-07-14	—	—	US	disclosed
US-20140018506-A1	BRIDGED METALLOCENE CATALYSTS	BOREALIS AG (AT)	2014-01-16	—	—	US	disclosed
US-20140018506-A1	BRIDGED METALLOCENE CATALYSTS	BOREALIS AG (AT)	2014-01-16	—	—	US	disclosed