Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415475 | 0.92 | PIK3R1 (0.37) | GPR119SCD5PIK3R1PIK3CATNKS | |
| SCHEMBL415417 | 0.81 | CHRNA7 (0.39) | GPR119SCD5PIK3R1PIK3CATNKS | |
| SCHEMBL15423390 | 0.80 | CHRNA7 (0.38) | GPR119SCD5PIK3R1PIK3CATNKS | |
| SCHEMBL24484588 | 0.66 | USP2 (0.52) | GPR119 | |
| SCHEMBL24484590 | 0.64 | USP2 (0.54) | GPR119 | |
| SCHEMBL413348 | 0.64 | USP2 (0.45) | GPR119SCD5PIK3R1PIK3CA | |
| SCHEMBL1975320 | 0.61 | SLC6A2 (0.44) | CHRNA7HTR3A | |
| SCHEMBL5761284 | 0.61 | CHRNA7 (0.37) | CHRNA7HTR3A | |
| SCHEMBL414018 | 0.61 | SLC6A2 (0.44) | CHRNA7HTR3A | |
| SCHEMBL1819759 | 0.61 | USP2 (0.49) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684871-B1 | Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives | HOFFMANN LA ROCHE (CH) | 2016-05-04 | — | — | EP | disclosed |
| EP-2684871-A1 | Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives | F. Hoffmann-La Roche AG (CH) | 2014-01-15 | — | — | EP | disclosed |