Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 2/20 | 0.34 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542431 | 1.00 | CHRNA7 (0.42) | CHRNA7KCNH2PIK3CDABL1LRRK2 | |
| SCHEMBL5438388 | 0.94 | CHRNA7 (0.39) | CHRNA7KCNH2PIK3CDABL1LRRK2 | |
| SCHEMBL1542591 | 0.79 | CHRNA7 (0.47) | CHRNA7KCNH2PIK3CDABL1LRRK2 | |
| SCHEMBL6527516 | 0.79 | CHRNA7 (0.47) | CHRNA7KCNH2PIK3CDABL1LRRK2 | |
| Fumaric Acid SCHEMBL1542496 | 0.72 | CHRNA7 (0.42) | CHRNA7KCNH2PIK3CDABL1PIK3CB | |
| Fumaric Acid SCHEMBL1542499 | 0.72 | CHRNA7 (0.42) | CHRNA7KCNH2PIK3CDABL1PIK3CB | |
| SCHEMBL5830444 | 0.67 | PIK3CD (0.58) | CHRNA7KCNH2PIK3CDABL1PIK3CB | |
| SCHEMBL30557210 | 0.65 | PIK3CD (0.58) | CHRNA7KCNH2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1542537 | 0.65 | CHRNA7 (0.64) | CHRNA7KCNH2ABL1 | |
| SCHEMBL5830239 | 0.64 | PIK3CD (0.67) | CHRNA7KCNH2PIK3CDABL1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308875-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives as .alpha.7 nAChR modulators | Abbott Laboratories (US) | 2011-04-13 | — | — | EP | disclosed |