Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.51 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.51 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 8/20 | 0.50 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831050 | 0.83 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL10945814 | 0.81 | PIK3CD (0.75) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL5831286 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL31675815 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL5830444 | 0.79 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL11992420 | 0.79 | PIP4K2A (0.58) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL29954839 | 0.79 | HPGDS (0.54) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL26260000 | 0.78 | ATM (0.50) | — | |
| SCHEMBL20540332 | 0.78 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGASH1LCSNK2B | |
| SCHEMBL29712113 | 0.77 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CGPIP4K2APIP4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053086-B2 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040097497-A1 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2004-05-20 | — | — | US | disclosed |
| US-6635640-B2 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2003-10-21 | — | — | US | disclosed |
| EP-1296975-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020187978-A1 | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2002-12-12 | — | — | US | disclosed |
| WO-2002002551-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187978-A1 | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | CDK2, CDK20, CDK3 | PIK3CD 214/4885PIK3CB 143/4885PIK3CG 248/4885 |
| US-20040097497-A1 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | CDK2, CDK20, CDK3 | PIK3CD 214/4885PIK3CB 143/4885PIK3CG 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.