Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.83 |
| ▸ | MMP2 | P08253 | 19/20 | 0.83 |
| ▸ | MMP9 | P14780 | 13/20 | 0.83 |
| ▸ | MMP3 | P08254 | 7/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.83 |
| ▸ | MMP12 | P39900 | 1/20 | 0.83 |
| ▸ | MMP14 | P50281 | 1/20 | 0.83 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.83 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.83 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.83 |
| ▸ | MMP1 | P03956 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038872 | 1.00 | ADAM10 (0.83) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL4337359 | 1.00 | ADAM10 (0.83) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL1366994 | 0.92 | ADAM10 (0.83) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL1366294 | 0.92 | ADAM10 (0.83) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL17288026 | 0.91 | ADAM10 (0.82) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL4323548 | 0.91 | ADAM10 (0.82) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL209111 | 0.91 | ADAM10 (1.00) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL1366486 | 0.91 | ADAM10 (1.00) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL4336513 | 0.90 | ADAM10 (0.70) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL4342726 | 0.90 | ADAM10 (0.68) | ADAM10MMP2MMP9MMP3ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637497-B2 | AZA spiro alkane derivatives as inhibitors of metalloproteases | INCYTE CORPORATION (US) | 2014-01-28 | — | — | US | disclosed |