ADAM10 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL206346	1.00	20/20
SCHEMBL207541	1.00	20/20
SCHEMBL207861	1.00	20/20
SCHEMBL209111	1.00	20/20
SCHEMBL1363578	1.00	20/20
SCHEMBL1363704	1.00	20/20
SCHEMBL1363723	1.00	20/20
SCHEMBL1363898	1.00	20/20
SCHEMBL1363900	1.00	20/20
SCHEMBL1364081	1.00	20/20
SCHEMBL1364108	1.00	20/20
SCHEMBL1364132	1.00	20/20
SCHEMBL1364161	1.00	20/20
SCHEMBL1364254	1.00	20/20
SCHEMBL1364266	1.00	20/20
SCHEMBL1364342	1.00	20/20
SCHEMBL1364417	1.00	20/20
SCHEMBL1364431	1.00	20/20
SCHEMBL1364454	1.00	20/20
SCHEMBL1364544	1.00	20/20

Clinical trials — most relevant to ADAM10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus.	PHASE4	COMPLETED
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment	PHASE3	NOT_YET_RECRUITING
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery	PHASE1/PHASE2	UNKNOWN
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer	PHASE1	COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Exercise and the Receptor for Advanced Glycation End Products (RAGE)	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia	nan	UNKNOWN
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia	nan	UNKNOWN
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Peri-implantitis and MMP-8	nan	COMPLETED
Infection, Sepsis and Meningitis in Surinamese Neonates	nan	COMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma	nan	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Pharmacokinetics of Low Molecular Weight Heparin in Cancer Patients	nan	COMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study Micro AAA	nan	UNKNOWN
The Biologic Basis of Hernia Formation	nan	COMPLETED
Pathology, Venous Disease, and Clinical Correlations	nan	UNKNOWN
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADAM10 binder may also engage these)

Protein	Name	Similarity
O77633	—	1.000	O77633 →
Q10743	—	1.000	Q10743 →
Q10741	—	1.000	Q10741 →
O35598	—	1.000	O35598 →
Q8JIY1	—	1.000	Q8JIY1 →
Q9Z1K9	—	0.997	Q9Z1K9 →
Q9Z0F8	—	0.996	Q9Z0F8 →
Q9VAC5	—	0.994	Q9VAC5 →
G5EFD9	—	0.992	G5EFD9 →
G5ECS8	—	0.992	G5ECS8 →
Q19791	—	0.992	Q19791 →
Q9UKP5	—	0.992	Q9UKP5 →
O77636	—	0.991	O77636 →
ADAM17	Disintegrin and metalloproteinase domain-containing protein 17	0.991	landscape →
A4PBQ9	—	0.990	A4PBQ9 →
P59510	—	0.990	P59510 →
P86392	—	0.989	P86392 →
Q61YG1	—	0.989	Q61YG1 →
P11584	—	0.988	P11584 →
P12607	—	0.988	P12607 →
Q98SP2	—	0.988	Q98SP2 →
Q4VM08	—	0.988	Q4VM08 →
P0DM87	—	0.987	P0DM87 →
MMP14	Matrix metalloproteinase-14	0.987	landscape →
Q94316	—	0.987	Q94316 →
J9Z332	—	0.987	J9Z332 →
Q90YA6	—	0.987	Q90YA6 →
ITGB1	Integrin beta-1	0.987	landscape →
D4DCV9	—	0.987	D4DCV9 →
Q90495	—	0.987	Q90495 →