Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 3/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15263145 | 1.00 | HRH3 (0.43) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15263144 | 1.00 | HRH3 (0.43) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15262814 | 0.92 | PDE4B (0.40) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15262812 | 0.92 | PDE4B (0.40) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15263015 | 0.92 | PDE4B (0.40) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15261932 | 0.92 | HRH3 (0.50) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15262719 | 0.88 | GRM5 (0.45) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL15829217 | 0.78 | FPR2 (0.53) | HRH3CYP2D6RORCMAPTSMN1; SMN2 | |
| SCHEMBL15830270 | 0.77 | KMT2A (0.49) | HRH3CYP2D6RORCCHRM4POLB | |
| SCHEMBL17851395 | 0.76 | TP53 (0.35) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855419-B1 | NEW INDANYLOXYPHENYLCYCLOPROPANECARB OXYLIC ACIDS | BOEHRINGER INGELHEIM INT (DE) | 2017-03-01 | — | — | EP | disclosed |
| US-8633182-B2 | Indanyloxyphenylcyclopropanecarboxylic acids | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-21 | — | — | US | disclosed |
| US-8633182-B2 | Indanyloxyphenylcyclopropanecarboxylic acids | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-21 | — | — | US | disclosed |
| WO-2013178575-A1 | NEW INDANYLOXYPHENYLCYCLOPROPANECARB OXYLIC ACIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-12-05 | — | — | WO | disclosed |