Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 20/20 | 0.60 |
| ▸ | PTGDR | Q13258 | 10/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088522 | 0.84 | PTGDR2 (0.64) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL3663654 | 0.82 | PTGDR2 (0.65) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL15428826 | 0.82 | PTGDR2 (0.65) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL3091930 | 0.79 | PTGDR2 (0.61) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL3097129 | 0.79 | PTGDR2 (0.61) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL2187304 | 0.79 | PTGDR2 (0.40) | PTGDR2PTGDRTBXA2RCYP2C9DRD2 | |
| SCHEMBL15280008 | 0.78 | PTGDR2 (0.58) | PTGDR2TBXA2R | |
| SCHEMBL3092003 | 0.75 | PTGDR2 (0.53) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL12417152 | 0.74 | PTGDR2 (0.78) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 | |
| SCHEMBL15445016 | 0.74 | PTGDR2 (0.55) | PTGDR2PTGDRTBXA2RCYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346865-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK CANADA INC (CA) | 2015-07-15 | — | — | EP | disclosed |
| US-8637671-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK CANADA INC. (CA) | 2014-01-28 | — | — | US | disclosed |