Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253563 | 0.82 | PTGDR2 (0.49) | PTGDR2PTGDRCYP2C9MEN1KMT2A | |
| SCHEMBL3092008 | 0.77 | PTGDR2 (0.35) | PTGDR2PTGDRCYP2C9MEN1KMT2A | |
| SCHEMBL15428825 | 0.76 | PTGDR2 (0.56) | PTGDR2PTGDRCYP2C9KDM4EALDH1A1 | |
| SCHEMBL15428827 | 0.73 | PTGDR2 (0.56) | PTGDR2PTGDRCYP2C9EGFRCYP3A4 | |
| SCHEMBL15428824 | 0.72 | PTGDR2 (0.55) | PTGDR2PTGDRCYP2C9KDM4EEGFR | |
| SCHEMBL15436634 | 0.71 | PTGDR2 (0.52) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL2188991 | 0.70 | PTGDR2 (0.61) | PTGDR2PTGDRCYP2C9CYP3A4 | |
| SCHEMBL2189699 | 0.69 | PTGDR2 (0.60) | PTGDR2PTGDRCYP2C9CYP3A4 | |
| SCHEMBL2188018 | 0.69 | PTGDR2 (0.63) | PTGDR2PTGDRCYP2C9CYP3A4 | |
| SCHEMBL15428833 | 0.68 | PTGDR2 (0.51) | PTGDR2PTGDRCYP2C9KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346865-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK CANADA INC (CA) | 2015-07-15 | — | — | EP | disclosed |
| US-8637671-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK CANADA INC. (CA) | 2014-01-28 | — | — | US | disclosed |