Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428883 | 0.80 | EPHX1 (0.39) | MAPTCACNA1BAPBA1 | |
| SCHEMBL14795167 | 0.77 | KDM4E (0.31) | — | |
| SCHEMBL2076964 | 0.70 | SUCNR1 (0.33) | — | |
| Tetrahydrofuran SCHEMBL28312832 | 0.69 | ALDH1A1 (0.44) | — | |
| Tetrahydrofuran SCHEMBL28292703 | 0.68 | ALDH1A1 (0.42) | — | |
| SCHEMBL18977803 | 0.67 | HDAC1 (0.31) | — | |
| Tetrahydrofuran SCHEMBL11243708 | 0.66 | ALDH1A1 (0.40) | — | |
| SCHEMBL3644508 | 0.64 | CHEK1 (0.41) | MAPT | |
| SCHEMBL31250863 | 0.63 | GCK (0.32) | — | |
| SCHEMBL3418328 | 0.61 | EPHX1 (0.36) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346831-B1 | HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-01-07 | — | — | EP | disclosed |
| US-8637550-B2 | Heteroaryl diamide compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-28 | — | — | US | disclosed |