Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 19/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428866 | 0.85 | MMP13 (0.48) | MMP13MMP8MMP2 | |
| SCHEMBL1316391 | 0.83 | MMP13 (0.56) | MMP13MMP8 | |
| SCHEMBL1318496 | 0.82 | MMP13 (0.59) | MMP13MMP8 | |
| SCHEMBL1315492 | 0.82 | MMP13 (0.53) | MMP13 | |
| SCHEMBL1315788 | 0.80 | MMP13 (0.63) | MMP13 | |
| SCHEMBL1320162 | 0.80 | MMP13 (0.51) | MMP13MMP8 | |
| SCHEMBL1317619 | 0.80 | MMP13 (0.55) | MMP13 | |
| SCHEMBL1316891 | 0.80 | MMP13 (0.65) | MMP13MMP8 | |
| SCHEMBL1317556 | 0.79 | MMP13 (0.80) | MMP13 | |
| SCHEMBL1316751 | 0.78 | MMP13 (0.79) | MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346831-B1 | HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-01-07 | — | — | EP | disclosed |
| US-8637550-B2 | Heteroaryl diamide compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-28 | — | — | US | disclosed |