Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542896 | 0.83 | SCN9A (0.40) | SCN9AKCNA3PDE4DMAPTMTNR1B | |
| SCHEMBL2180079 | 0.76 | KCNA3 (0.42) | SCN9AKCNA3PDE4DMTNR1B | |
| SCHEMBL2179672 | 0.75 | LMNA (0.41) | SCN9AKCNA3PDE4DMAPTMTNR1B | |
| SCHEMBL1542204 | 0.73 | GRIN2D (0.42) | SCN9APDE4DMAPTLMNANPC1 | |
| SCHEMBL3612488 | 0.72 | KCNA3 (0.64) | KCNA3 | |
| SCHEMBL2180340 | 0.72 | GRIN2D (0.41) | SCN9APDE4D | |
| SCHEMBL3757808 | 0.70 | PDE4D (0.45) | SCN9AKCNA3PDE4D | |
| SCHEMBL3763110 | 0.70 | PDE4D (0.43) | SCN9AKCNA3PDE4DMTNR1BLMNA | |
| SCHEMBL1541608 | 0.69 | PDE4D (0.51) | SCN9APDE4DMTNR1BLMNASMN1; SMN2 | |
| SCHEMBL3754114 | 0.69 | KCNA3 (0.41) | SCN9AKCNA3LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303850-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | Bionomics Limited (AU) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009149508-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2009-12-17 | — | — | WO | disclosed |