Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15430488 | 0.80 | PDE4A (0.40) | DYRK1BEGFRERBB2CLK1CLK2 | |
| SCHEMBL14477603 | 0.78 | ALDH1A1 (0.44) | DYRK1BALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL31121065 | 0.70 | PIK3CA (0.59) | DYRK1BALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL12715958 | 0.70 | PIK3CA (0.59) | DYRK1BMAPKAPK2PIK3CACLK2CLK4 | |
| SCHEMBL24478623 | 0.69 | MAP4K4 (0.53) | DYRK1BALDH1A1NR4A2USP2TSHR | |
| SCHEMBL12690540 | 0.68 | EGFR (0.63) | MEN1KMT2AEGFRERBB2 | |
| SCHEMBL31485234 | 0.68 | DYRK1A (0.53) | DYRK1BNR4A2PIK3CA | |
| SCHEMBL17206393 | 0.68 | EGFR (0.43) | DYRK1BPIK3CAMEN1KMT2AEGFR | |
| SCHEMBL30051309 | 0.67 | NR4A2 (0.66) | DYRK1BALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL1888577 | 0.67 | NR4A2 (0.66) | DYRK1BALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710221-B2 | Process and intermediates for preparing lapatinib | SCINOPHARM TAIWAN, LTD. (TW) | 2014-04-29 | — | — | US | disclosed |
| US-20140024829-A1 | PROCESS AND INTERMEDIATES FOR PREPARING LAPATINIB | SCINOPHARM TAIWAN, LTD. (TW) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024829-A1 | PROCESS AND INTERMEDIATES FOR PREPARING LAPATINIB | EGFR, ABL1, ERBB2 | DYRK1B 535/4885ALDH1A1 2778/4885MAPT 1755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.