SCHEMBL15433385

SCHEMBL15433385

C/C=C/C(F)=C(\F)c1ccc(-c2ccc(-c3ccc(-c4cc(F)c(F)c(F)c4)cc3)c(F)c2)cc1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 3/20 0.33
ANPEP P15144 8/20 0.32
RARB P10826 1/20 0.32
APP P05067 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
KIF11 P52732 1/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15433427 0.88 KIF11 (0.37) ERN1RARBAPPKIF11
SCHEMBL15433400 0.83 ESR1 (0.30) RARB
SCHEMBL15433546 0.81 RARB (0.37) RARB
SCHEMBL15433542 0.81 RARB (0.36) RARB
SCHEMBL15433235 0.80
SCHEMBL15433623 0.80 ALOX5AP (0.33) ERN1ANPEPAPP
SCHEMBL15433185 0.78 RARB (0.33) ERN1ANPEPRARBAPPCYP3A4
SCHEMBL15433382 0.78 RARB (0.33) ERN1ANPEPRARBAPPCYP3A4
SCHEMBL15433487 0.78 CYP17A1 (0.32) ERN1RARB
SCHEMBL15433172 0.77 KIF11 (0.39) ANPEPRARBAPPCYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed