Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15434144 | 0.87 | IP6K1 (0.46) | GAAESR1SMN1; SMN2HTTDHODH | |
| SCHEMBL15434135 | 0.87 | IP6K1 (0.46) | GAAESR1SMN1; SMN2HTTDHODH | |
| SCHEMBL15434108 | 0.87 | IP6K1 (0.46) | GAAESR1SMN1; SMN2HTTDHODH | |
| SCHEMBL13581097 | 0.86 | LMNA (0.41) | GAAFFAR4SCN9ALMNADHODH | |
| SCHEMBL15434139 | 0.85 | HTT (0.44) | GAAESR1SMN1; SMN2HTTFFAR4 | |
| SCHEMBL15434162 | 0.83 | GAA (0.50) | GAAESR1SMN1; SMN2HTTLMNA | |
| SCHEMBL15434121 | 0.82 | GAA (0.45) | GAAESR1SMN1; SMN2HTTLMNA | |
| SCHEMBL15434120 | 0.81 | GAA (0.50) | GAAESR1SMN1; SMN2HTTLMNA | |
| SCHEMBL13580962 | 0.81 | KDM4E (0.46) | GAAESR1SMN1; SMN2HTTSCN9A | |
| SCHEMBL15434159 | 0.80 | SMN1; SMN2 (0.53) | GAAESR1SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633245-B2 | PAI-1 inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2014-01-21 | — | — | US | disclosed |