Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | PPARD | Q03181 | 5/20 | 0.48 |
| ▸ | PPARA | Q07869 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15434106 | 0.91 | FFAR1 (0.48) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434118 | 0.88 | PPARD (0.46) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434180 | 0.86 | NPSR1 (0.47) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434111 | 0.86 | NPSR1 (0.47) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434146 | 0.86 | PPARG (0.45) | PPARGPPARDPPARAALDH1A1FFAR1 | |
| SCHEMBL15434102 | 0.86 | FFAR1 (0.50) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434129 | 0.85 | PPARD (0.46) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434114 | 0.84 | PPARG (0.49) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434138 | 0.84 | FFAR4 (0.47) | PPARGPPARDPPARAFFAR1FFAR4 | |
| SCHEMBL15434105 | 0.83 | PPARG (0.43) | PPARGPPARDPPARAFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633245-B2 | PAI-1 inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2014-01-21 | — | — | US | disclosed |