Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543899 | 0.82 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1543486 | 0.81 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1543738 | 0.80 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1543346 | 0.77 | PIK3CA (0.87) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1543929 | 0.72 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL27470939 | 0.69 | CYP3A4 (0.57) | PIK3CAKCNH2CYP3A4CHRM1DRD3 | |
| SCHEMBL1543335 | 0.69 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL27666325 | 0.68 | KCNH2 (0.73) | CYP2C9KCNH2CYP3A4CHRM1DRD3 | |
| SCHEMBL1543905 | 0.66 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL1544491 | 0.65 | NPC1 (0.57) | PIK3CAPIK3CDHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | claimed |
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |