Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.59 |
| ▸ | MTOR | P42345 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | PRKDC | P78527 | 2/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543346 | 0.88 | PIK3CA (0.87) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543898 | 0.83 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543765 | 0.83 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543487 | 0.82 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543536 | 0.82 | PIK3CA (0.75) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1544261 | 0.81 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543335 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543905 | 0.78 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543567 | 0.77 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543975 | 0.77 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | claimed |
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |