Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 13/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477336 | 0.85 | CYP11B2 (0.46) | CYP11B2CYP11B1SLC22A12 | |
| SCHEMBL3750955 | 0.84 | CYP11B2 (0.47) | CYP11B2CYP11B1SLC22A12CTSCAKT1 | |
| SCHEMBL3755082 | 0.84 | CYP11B2 (0.44) | CYP11B2CYP11B1AKT1 | |
| SCHEMBL15435143 | 0.82 | CYP11B2 (0.48) | CYP11B2CYP11B1SLC22A12 | |
| SCHEMBL3750947 | 0.82 | CYP11B2 (0.46) | CYP11B2CYP11B1SLC22A12CTSCAKT1 | |
| SCHEMBL3751453 | 0.82 | CYP11B2 (0.43) | CYP11B2CYP11B1SLC22A12 | |
| SCHEMBL3755079 | 0.82 | CYP11B2 (0.44) | CYP11B2CYP11B1SLC22A12CTSCAKT1 | |
| SCHEMBL3751446 | 0.81 | CYP11B1 (0.43) | CYP11B2CYP11B1SLC22A12CTSCAKT1 | |
| SCHEMBL745296 | 0.80 | CYP11B2 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL745295 | 0.80 | CYP11B2 (0.47) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429995-B1 | ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2014-01-22 | — | — | EP | disclosed |