Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11316551 | 0.84 | ALDH1A1 (0.64) | ALDH1A1FOLH1TAS1R3TAS1R1BIRC2 | |
| SCHEMBL5812880 | 0.84 | ALDH1A1 (0.64) | ALDH1A1FOLH1TAS1R3TAS1R1BIRC2 | |
| SCHEMBL245758 | 0.84 | ALDH1A1 (0.64) | ALDH1A1FOLH1TAS1R3TAS1R1BIRC2 | |
| SCHEMBL10795132 | 0.81 | ALDH1A1 (0.60) | ALDH1A1FOLH1TAS1R3TAS1R1MEN1 | |
| SCHEMBL21488669 | 0.81 | ALDH1A1 (0.60) | ALDH1A1FOLH1TAS1R3TAS1R1MEN1 | |
| SCHEMBL5813383 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TAS1R3TAS1R1LMNAKMT2A | |
| SCHEMBL5813379 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TAS1R3TAS1R1LMNAKMT2A | |
| SCHEMBL5808681 | 0.81 | ALDH1A1 (0.60) | ALDH1A1FOLH1TAS1R3TAS1R1MEN1 | |
| SCHEMBL5808683 | 0.81 | ALDH1A1 (0.60) | ALDH1A1FOLH1TAS1R3TAS1R1MEN1 | |
| SCHEMBL7611217 | 0.80 | ALDH1A1 (0.39) | ALDH1A1FOLH1TAS1R3TAS1R1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687206-A1 | Targeting of EWS-FLI1 as anti-tumor therapy | Georgetown University (US) | 2014-01-22 | — | — | EP | disclosed |