Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.37 |
| ▸ | DNA2 | P51530 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 5/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276542 | 0.85 | ALDH1A1 (0.39) | ATM | |
| SCHEMBL762317 | 0.84 | ATM (0.33) | SIRT5ATMTDP1CTSK | |
| SCHEMBL10123687 | 0.78 | PDGFRB (0.39) | ATMTDP1CTSKSRD5A2 | |
| SCHEMBL12909115 | 0.75 | ATM (0.35) | ATMTDP1 | |
| SCHEMBL27663200 | 0.72 | ATM (0.32) | ATMTDP1 | |
| SCHEMBL744523 | 0.72 | POLB (0.42) | — | |
| SCHEMBL762777 | 0.71 | TSHR (0.33) | — | |
| SCHEMBL10225351 | 0.70 | TDP1 (0.38) | SIRT5ATMTDP1FBP1 | |
| SCHEMBL3614741 | 0.68 | AR (0.40) | ATM | |
| SCHEMBL275419 | 0.68 | MAPT (0.41) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957077-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2014-01-22 | — | — | EP | disclosed |