Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637732 | 0.81 | POLB (0.39) | SMN1; SMN2POLBMEN1KMT2AOPRM1 | |
| SCHEMBL2994530 | 0.76 | BRD4 (0.43) | SMN1; SMN2POLBCYP2C19CYP3A4MEN1 | |
| SCHEMBL28863648 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2POLBMEN1KMT2AGAA | |
| SCHEMBL12037341 | 0.73 | POLB (0.43) | SMN1; SMN2POLBKDM4EMEN1KMT2A | |
| SCHEMBL9632673 | 0.73 | CYP4F2 (0.41) | SMN1; SMN2KDM4ECYP2C19CYP3A4MEN1 | |
| SCHEMBL4288590 | 0.70 | POLB (0.41) | SMN1; SMN2POLBKDM4EMEN1KMT2A | |
| SCHEMBL18191201 | 0.70 | CYP2C19 (0.38) | CYP2C19MEN1KMT2A | |
| SCHEMBL5949812 | 0.70 | POLB (0.41) | SMN1; SMN2POLBKDM4EMEN1KMT2A | |
| SCHEMBL27971078 | 0.70 | KDM4E (0.35) | SMN1; SMN2POLBKDM4ECYP2C19CYP3A4 | |
| SCHEMBL7301501 | 0.69 | TSHR (0.41) | POLBCYP2C19CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307377-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Limited (GB) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009153720-A1 | NICOTINAMIDE DERIVATIVES | PFIZER LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |