Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347632 | 0.80 | TP53 (0.40) | MAPTTP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL349746 | 0.71 | TP53 (0.40) | MAPTTP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL348437 | 0.69 | MAPT (0.38) | POLBMAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL30434436 | 0.66 | BRD4 (0.47) | MAPTTP53RXFP1BRD4 | |
| SCHEMBL145199 | 0.66 | BRD4 (0.47) | MAPTTP53RXFP1BRD4 | |
| SCHEMBL1427544 | 0.65 | GAA (0.55) | GAAPOLBMAPTKDM4EALDH1A1 | |
| SCHEMBL1427541 | 0.64 | GAA (0.61) | GAAPOLBKDM4EALDH1A1TDP1 | |
| SCHEMBL28782008 | 0.63 | JAK2 (0.44) | MAPTTP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL23783633 | 0.62 | GAA (0.54) | GAAPOLBKDM4EALDH1A1TDP1 | |
| SCHEMBL349170 | 0.61 | XDH (0.44) | GAAMAPTTP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118074-B1 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP (CA) | 2014-01-22 | — | — | EP | disclosed |