Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5597719 | 0.86 | ESR2 (0.54) | FYNMAPTHPGDPSEN1PSEN2 | |
| SCHEMBL14458205 | 0.83 | MAPT (0.46) | MAPTSMN1; SMN2NPSR1HPGDPSEN1 | |
| SCHEMBL5598135 | 0.78 | STAT3 (0.47) | FYNMAPTSMN1; SMN2HPGDPSEN1 | |
| SCHEMBL25645955 | 0.78 | ESR2 (0.44) | FYNMAPTALOX15SMN1; SMN2NPSR1 | |
| SCHEMBL5597739 | 0.76 | BACE1 (0.46) | FYNMAPTSMN1; SMN2NPSR1HPGD | |
| SCHEMBL16804440 | 0.73 | MEN1 (0.50) | MAPTSMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL16344869 | 0.72 | IDO1 (0.42) | FYNMAPTNPSR1HPGDMEN1 | |
| SCHEMBL17372934 | 0.72 | MAPT (0.53) | MAPTSMN1; SMN2NPSR1HPGDMEN1 | |
| SCHEMBL5385380 | 0.72 | GABRG2 (0.51) | — | |
| SCHEMBL17279861 | 0.71 | KMT2A (0.47) | MAPTNPC1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687513-A1 | Drugs for inhibiting aggregation of proteins invoved in diseases linked to protein aggregation and/or neurodegenerative diseases | Ludwig-Maximilians-Universität München (DE) | 2014-01-22 | — | — | EP | disclosed |