Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 5/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15006653 | 0.84 | PTGDR2 (0.44) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL15436290 | 0.82 | TBXA2R (0.38) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL2187304 | 0.75 | PTGDR2 (0.40) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL15436289 | 0.72 | — | — | |
| SCHEMBL12002786 | 0.70 | CYP2C9 (0.36) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL12002746 | 0.68 | PTGDR (0.36) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL15436295 | 0.66 | PTGDR2 (0.55) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL15436636 | 0.66 | PTGDR2 (0.55) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL15436284 | 0.65 | CYP2C9 (0.33) | PTGDRPTGDR2TBXA2RCYP2C9 | |
| SCHEMBL15165873 | 0.65 | AKR1C3 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401269-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-29 | — | — | EP | disclosed |