SCHEMBL15437481

SCHEMBL15437481

c1ccc(-n2c(-c3ccc(-c4nc5cccnc5n4-c4ccccc4)cc3)nc3ccccc32)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.57
ESR2 Q92731 1/20 0.57
ALDH1A1 P00352 1/20 0.53
TSHR P16473 1/20 0.53
CYP2C19 P33261 1/20 0.53
GRIA1 P42261 1/20 0.52
CACNG8 Q8WXS5 1/20 0.52
CACNG2 Q9Y698 1/20 0.52
MAPK1 P28482 1/20 0.50
HTT P42858 1/20 0.50
AKT1 P31749 8/20 0.49
PTGS2 P35354 1/20 0.47
AKT2 P31751 3/20 0.47
RECQL P46063 1/20 0.47
PRKACA P17612 1/20 0.46
RPS6KB1 P23443 1/20 0.46
GSK3B P49841 1/20 0.46
ROCK1 Q13464 1/20 0.46
MEN1 O00255 1/20 0.44
HSP90AA1 P07900 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18082487 0.99 ESR1 (0.56) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL15197419 0.93 ESR1 (0.52) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL13023868 0.93 ESR1 (0.52) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL804897 0.93 ALDH1A1 (0.60) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL13916708 0.91 ALDH1A1 (0.58) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL8805096 0.90 ALDH1A1 (0.64) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL13916702 0.88 ALDH1A1 (0.56) ESR1ESR2ALDH1A1TSHRCYP2C19
SCHEMBL14582732 0.87 ALDH1A1 (0.55) ALDH1A1TSHRCYP2C19AKT1AKT2
SCHEMBL804992 0.86 ESR2 (0.73) ESR1ESR2ALDH1A1GRIA1CACNG8
SCHEMBL16201579 0.86 MAPK1 (0.51) ESR1ESR2ALDH1A1TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140021461-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENCE ELEMENT, AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING THE MATERIAL IDEMITSU KOSAN CO., LTD. (JP) 2014-01-23 US disclosed
US-20140021461-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENCE ELEMENT, AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING THE MATERIAL IDEMITSU KOSAN CO., LTD. (JP) 2014-01-23 US disclosed