Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.73 |
| ▸ | SOAT2 | O75908 | 3/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060223 | 0.85 | DGAT1 (0.72) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL435175 | 0.85 | DGAT1 (1.00) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL12045609 | 0.84 | DGAT1 (0.88) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL462112 | 0.83 | DGAT1 (0.87) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL374783 | 0.73 | DGAT1 (1.00) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL9984741 | 0.72 | DGAT1 (0.67) | DGAT1SOAT2ALDH1A1KDM4E | |
| SCHEMBL12045604 | 0.72 | DGAT1 (0.88) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL13189567 | 0.69 | DGAT1 (0.67) | DGAT1SOAT2L3MBTL1MEN1KMT2A | |
| SCHEMBL374805 | 0.69 | DGAT1 (0.69) | DGAT1SOAT2CYP2C9 | |
| SCHEMBL438393 | 0.68 | DGAT1 (0.63) | DGAT1SOAT2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637507-B2 | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORP. (US) | 2014-01-28 | — | — | US | disclosed |