Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.77 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984504 | 1.00 | DGAT1 (0.77) | DGAT1SOAT2KDRMAPT | |
| SCHEMBL9984501 | 1.00 | DGAT1 (0.77) | DGAT1SOAT2KDRMAPT | |
| SCHEMBL12045628 | 0.93 | DGAT1 (0.71) | DGAT1SOAT2KDRMAPT | |
| SCHEMBL9984802 | 0.87 | DGAT1 (0.78) | DGAT1SOAT2KDRMAPT | |
| SCHEMBL10260116 | 0.87 | DGAT1 (1.00) | DGAT1SOAT2KDR | |
| SCHEMBL10198101 | 0.87 | DGAT1 (1.00) | DGAT1SOAT2KDR | |
| SCHEMBL409072 | 0.87 | DGAT1 (1.00) | DGAT1SOAT2KDR | |
| SCHEMBL10197384 | 0.83 | DGAT1 (0.86) | DGAT1SOAT2KDRMAPT | |
| SCHEMBL9985305 | 0.83 | DGAT1 (0.76) | DGAT1SOAT2KDR | |
| SCHEMBL9985300 | 0.83 | DGAT1 (0.76) | DGAT1SOAT2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637507-B2 | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORP. (US) | 2014-01-28 | — | — | US | disclosed |