⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650579 | 1.00 | — | — | |
| SCHEMBL648003 | 1.00 | — | — | |
| SCHEMBL16327975 | 0.76 | — | — | |
| SCHEMBL13848749 | 0.72 | — | — | |
| SCHEMBL11163142 | 0.70 | — | — | |
| SCHEMBL8626148 | 0.70 | — | — | |
| SCHEMBL12704754 | 0.70 | — | — | |
| SCHEMBL11495563 | 0.70 | — | — | |
| SCHEMBL14297400 | 0.70 | — | — | |
| SCHEMBL13792239 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017069601-A1 | SUBSTITUTED AMINOALKYLAZOLES AS MALARIAL ASPARTIC PROTEASE INHIBITORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2017-04-27 | — | — | WO | disclosed |
| EP-2640731-B9 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2015-11-25 | — | — | EP | disclosed |
| EP-2640731-B1 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2015-07-08 | — | — | EP | disclosed |
| US-9062060-B2 | Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-23 | — | — | US | disclosed |
| US-9062060-B2 | Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-23 | — | — | US | disclosed |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-8796304-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2014-08-05 | — | — | US | disclosed |
| US-8796304-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2014-08-05 | — | — | US | disclosed |
| US-8703776-B2 | Agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20070179188-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
| US-20070179188-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
| US-20070142371-A1 | Anti-Cytokine Heterocyclic Compounds | COGAN DEREK | 2007-06-21 | — | — | US | disclosed |
| US-20070142371-A1 | Anti-Cytokine Heterocyclic Compounds | COGAN DEREK | 2007-06-21 | — | — | US | disclosed |
| US-7214802-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-7214802-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| EP-1723144-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |
| US-20050272779-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |