⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342145 | 0.88 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL62671 | 0.78 | — | — | |
| SCHEMBL42860 | 0.76 | — | — | |
| SCHEMBL207945 | 0.76 | — | — | |
| SCHEMBL207946 | 0.76 | — | — | |
| SCHEMBL8753101 | 0.76 | TSHR (0.50) | — | |
| SCHEMBL29111195 | 0.74 | — | — | |
| SCHEMBL6985828 | 0.74 | ALDH1A1 (0.50) | — | |
| SCHEMBL4644488 | 0.72 | — | — | |
| SCHEMBL1363305 | 0.71 | ALDH1A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951043-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-9115135-B2 | Process for the preparation of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine from 4-amino-2,5-dimethoxypyrimidine | DOW AGROSCIENCES LLC (US) | 2015-08-25 | — | — | US | disclosed |
| US-8822523-B2 | Carboxamide microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-09-02 | — | — | US | disclosed |
| US-20140081024-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE FROM 4-AMINO-2,5-DIMETHOXYPYRIMIDINE | DOW AGROSCIENCES LLC (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140031405-A1 | NOVEL CARBOXAMIDE MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-01-30 | — | — | US | disclosed |